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关于人尿中免疫反应性促黄体生成激素释放激素（LH-RH）样肽性质的进一步研究。

Further studies on the nature of the immunoreactive luteinizing hormone-releasing hormone (LH-RH)-like peptide in human urine.

作者信息

Jeffcoate S L, Holland D T

出版信息

Acta Endocrinol (Copenh). 1975 Feb;78(2):232-38. doi: 10.1530/acta.0.0780232.

DOI:10.1530/acta.0.0780232
PMID:1090101
Abstract

The chemical nature of the immunoreactive LH-RH-like peptide found in human urine has been investigated using ion-exchange chromatography on carboxymethyl (CM)-cellulose and a radioimmunoassay for LH-RH. A single immunoreactive substance was found in urine after LH-RH administration and in urine samples from untreated subjects. This substance did not have the mobility of either the synthetic decapeptide nor the 3-10 octapeptide on CM-cellulose and the evidence suggests that it may be the 2-10 nonapeptide of LH-RH.

摘要

利用羧甲基（CM）纤维素离子交换色谱法和促黄体激素释放激素（LH-RH）放射免疫分析法，对人尿中发现的免疫反应性促黄体激素释放激素（LH-RH）样肽的化学性质进行了研究。给予LH-RH后尿液以及未经治疗受试者的尿液样本中均发现了一种单一的免疫反应性物质。该物质在CM纤维素上的迁移率既不同于合成十肽，也不同于3 - 10八肽，有证据表明它可能是LH-RH的2 - 10九肽。

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