Bourguignon J P, Dourcy C, Franchimont P
C R Seances Soc Biol Fil. 1976;170(1):200-6.
The existence of endogenous LH RH like immunoreactivity is shown in human urines after appropriate extraction, bu the radioimmunoassay of LH RH. In normaly cycling and menopausal women the quantities of endogenous hormone found in urines are greater after acid extraction than those found after extraction at pH 7. Furthermore, the increase observed by extraction in acidified methanol is directly correlated and proportional to the quantity of hormone assayable by extraction at pH 7. The hypothesis of urinary excretion of LH RH as a polymer of immunoreactive units is suggested by this study.
经适当提取后，在人尿中显示出内源性促黄体激素释放激素（LH RH）样免疫反应性，但采用LH RH放射免疫测定法。在正常月经周期和绝经后妇女中，尿液中发现的内源性激素量在酸提取后比在pH 7提取后更多。此外，在酸化甲醇中提取所观察到的增加与在pH 7提取可测定的激素量直接相关且成比例。本研究提出了LH RH以免疫反应性单位聚合物形式经尿液排泄的假说。
