Mendlewicz J, Fleiss J L, Cataldo M, Rainer J D
Arch Gen Psychiatry. 1975 Mar;32(3):309-14. doi: 10.1001/archpsyc.1975.01760210043002.
We interviewed available spouses and first-degree relatives of 140 bipolar and unipolar probands for current and past psychopathology, and assessed interrater reliability. Diagnoses based on direct interviews of relatives were compared with those based on reports of the probands and of all other interviewed family members. Probands underestimated the prevalence of affective illness and other psychiatric disorders in their relatives, and overestimated the age of onset of illness in their ill relatives. Probands reported more accurately about illness in their spouses and parents than in their siblings and children, but accuracy reached acceptable levels for spouses only. Diagnoses on relatives derived by combining reports of all other interviewed family members, including the proband, were slightly more accurate than those based on the proband's reports alone. Good accuracy was obtained only for reports about spouses.
我们采访了140名双相情感障碍和单相情感障碍先证者的在世配偶及一级亲属，了解他们当前及过去的精神病理学情况，并评估了评分者间信度。将基于对亲属直接访谈得出的诊断结果，与基于先证者及所有其他受访家庭成员报告得出的诊断结果进行比较。先证者低估了其亲属中情感性疾病及其他精神障碍的患病率，高估了患病亲属的发病年龄。先证者报告其配偶和父母患病情况的准确性高于报告其兄弟姐妹和子女的情况，但准确性仅在配偶方面达到了可接受水平。综合包括先证者在内的所有其他受访家庭成员的报告得出的亲属诊断结果，比仅基于先证者报告得出的诊断结果略准确。仅在关于配偶的报告方面获得了较高的准确性。
