动物细胞的信使核糖核酸代谢。非翻译序列和信使核糖核酸相关蛋白质的可能作用。
Messenger RNA metabolism of animal cells. Possible involvement of untranslated sequences and mRNA-associated proteins.
作者信息
Greenberg J R
出版信息
J Cell Biol. 1975 Feb;64(2):269-88. doi: 10.1083/jcb.64.2.269.
Abstract
The past several years have seen a virtual revolution in the study of eukaryotic mRNA. Among the notable recent achievements are the positive identification of mRNA precursors in HnRNA, the enumeration of the DNA sequences from which mRNA is transcribed, and the finding that mRNA in cultured cells is much more stable than was previously believed. One of most far-reaching discoveries has been the finding that mRNA in eukaryotes contains poly A. This discovery, aside from providing a powerful tool for mRNA isolation, has generated a large body of research into the properties and metabolism of poly A itself. In addition, the finding of a poly A-associated protein has given a renewed stimulus to the study of proteins associated with mRNA. This review is devoted to a discussion of these and related achievements, and some of their implications
摘要
在过去几年里，真核生物信使核糖核酸（mRNA）的研究发生了一场实实在在的革命。近期的显著成就包括在核内不均一核糖核酸（HnRNA）中明确鉴定出mRNA前体，确定转录mRNA的DNA序列，以及发现培养细胞中的mRNA比之前认为的要稳定得多。最具深远意义的发现之一是真核生物中的mRNA含有多聚腺苷酸（poly A）。这一发现不仅为mRNA的分离提供了强大工具，还引发了大量关于poly A自身特性和代谢的研究。此外，多聚腺苷酸结合蛋白的发现为与mRNA相关的蛋白质研究注入了新的活力。这篇综述致力于讨论这些及相关成就，以及它们的一些影响。
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