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在C3H品系小鼠中,β-葡萄糖醛酸酶部分缺乏导致糖胺聚糖积累。

Glycosaminoglycan accumulation with partial deficiency of beta-glucuronidase in the C3H strain of mice.

作者信息

Yatziv S, Erickson R P, Sandman R, Robertson W V

出版信息

Biochem Genet. 1978 Dec;16(11-12):1079-84. doi: 10.1007/BF00484528.

DOI:10.1007/BF00484528
PMID:109077
Abstract

Young (60--80 days) mice of the low beta-glucuronidase strain, C3H/HeJ, showed no differences in hepatic levels of glycosaminoglycans (GAGs) when compared to the randombred, "normal" Swiss-Webster mice of the same age. However, by 12 months of age hepatic GAG is nearly twice as high in C3H/HeJ mice as in Swiss-Webster mice. Studies of beta-glucuronidase, beta-galactosidase, and N-acetyl-beta-glucosaminidase in four tissues of the two types of mice at the two ages revealed that glucuronidase was the only enzyme with lower activity in the C3H/HeJ strain.

摘要

低β-葡萄糖醛酸酶品系C3H/HeJ的幼龄(60 - 80天)小鼠,与同龄的随机繁殖“正常”瑞士韦伯斯特小鼠相比,肝脏中糖胺聚糖(GAGs)水平无差异。然而,到12月龄时,C3H/HeJ小鼠肝脏中的GAG含量几乎是瑞士韦伯斯特小鼠的两倍。对这两种小鼠在两个年龄段的四种组织中的β-葡萄糖醛酸酶、β-半乳糖苷酶和N-乙酰-β-氨基葡萄糖苷酶的研究表明,葡萄糖醛酸酶是C3H/HeJ品系中唯一活性较低的酶。

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