来自秘鲁药用植物总状多鳞杜鹃的细胞毒性三萜酸。
Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa.
作者信息
Neto C C, Vaisberg A J, Zhou B N, Kingston D G, Hammond G B
出版信息
Planta Med. 2000 Jun;66(5):483-4. doi: 10.1055/s-2000-8583.
PMID:10909276
Abstract
Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 micrograms/mL respectively.
摘要
对多花多鳞杜英树皮和茎提取物进行细胞毒性导向分级分离，从而鉴定出了熊果酸、坡模酸、3 - O - 乙酰坡模酸和2 - 氧代坡模酸。坡模酸是细胞毒性最强的成分，对M - 14黑色素瘤和ME180宫颈癌具有特异性，其GI50值分别为6.9和8.3微克/毫升。
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