中间锦鸡儿茎皮中的细胞毒性三萜类化合物。
Cytotoxic triterpenes from stem bark of Physocarpus intermedius.
作者信息
Kim Y K, Yoon S K, Ryu S Y
出版信息
Planta Med. 2000 Jun;66(5):485-6. doi: 10.1055/s-2000-8585.
PMID:10909277
Abstract
Seven triterpenes (1-7), i.e., betulinic acid 1, ursolic acid 2, oleanolic acid 3, 3-O-caffeoyloleanolic acid 4, euscaphic acid 5, 2 alpha-hydroxyursolic acid 6 and maslinic acid 7 were isolated from the stem bark extract of P. intermedius as active principles responsible for the cytotoxicity against five cultured human tumor cell lines, i.e., A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.
摘要
从中间假人参茎皮提取物中分离出七种三萜类化合物（1-7），即桦木酸1、熊果酸2、齐墩果酸3、3-O-咖啡酰齐墩果酸4、川续断酸5、2α-羟基熊果酸6和山楂酸7，它们是对五种培养的人类肿瘤细胞系，即A549（非小细胞肺癌）、SK-OV-3（卵巢癌）、SK-MEL-2（黑色素瘤）、XF498（中枢神经系统）和HCT-15（结肠癌）具有细胞毒性的活性成分。
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