Hoyos L, Norris A, Vargaftig B B
RPR Pharmaceuticals, Collegeville, Pennsylvania 19426, USA.
Adv Ther. 2000 Jan-Feb;17(1):1-6. doi: 10.1007/BF02868025.
We evaluated nedocromil sodium in a guinea pig model of allergic conjunctivitis. Ten days after the animals were passively sensitized to ovalbumin, nedocromil sodium (2 mg) or normal saline was instilled into the conjunctival sac, followed by antigen challenge with ovalbumin (100 micrograms or 300 micrograms/10 microL). Conjunctival hyperemia, edema, and eyelid edema were evaluated at 10 minutes and 4 hours in the 100-microgram ovalbumin group. Eyes with nedocromil sodium exhibited fewer early and late clinical signs of allergic conjunctivitis than control eyes. Infiltrating eosinophils were counted at 24 hours in the 300-microgram ovalbumin group. Nedocromil sodium inhibited antigen-induced eosinophil infiltration into the limbus, fornix, and eyelids by 77%, 66%, and 74%, compared with controls. Nedocromil sodium can effectively suppress early- and late-phase conjunctival hyperemia, conjunctival edema, eyelid edema, and eosinophil infiltration in the guinea pig passive-sensitization model. Nedocromil sodium may represent a versatile option for the treatment of allergic conjunctivitis.
我们在豚鼠过敏性结膜炎模型中评估了奈多罗米钠。在动物被动致敏于卵清蛋白10天后，将奈多罗米钠（2毫克）或生理盐水滴入结膜囊，随后用卵清蛋白（100微克或300微克/10微升）进行抗原激发。在100微克卵清蛋白组中，于10分钟和4小时时评估结膜充血、水肿及眼睑水肿情况。使用奈多罗米钠的眼睛相较于对照眼睛，出现的过敏性结膜炎早期和晚期临床症状更少。在300微克卵清蛋白组中，于24小时时对浸润的嗜酸性粒细胞进行计数。与对照组相比，奈多罗米钠使抗原诱导的嗜酸性粒细胞向角膜缘、穹窿和眼睑的浸润分别减少了77%、66%和74%。在豚鼠被动致敏模型中，奈多罗米钠可有效抑制早期和晚期结膜充血、结膜水肿、眼睑水肿及嗜酸性粒细胞浸润。奈多罗米钠可能是治疗过敏性结膜炎的一种通用选择。
