van Eys J
Cancer. 1979 May;43(5 Suppl):2030-5. doi: 10.1002/1097-0142(197905)43:5+<2030::aid-cncr2820430711>3.0.co;2-s.
Overt malnutrition in children with cancer is seen with surprising frequency: up to 37.5% in a group of patients with disease metastatic to or from bone, and 17.5% in a group of newly diagnosed patients with abdominal or pelvic tumors. It appears more frequent in some cancers. e.g., Ewing's sarcoma, than in others, e.g., osteosarcoma. Criteria for diagnosis of overt malnutrition are applicable to the child with cancer. Such overt malnutrition can be successfully and safely treated with intravenous hyperalimentation (IVH). Marginal malnutrition is a state that can be inferred from clinical behavior, although it cannot be objectively diagnosed as yet. Early data suggest that deterioration to overt malnutrition can be averted through IVH. Such nutritional intervention may increase chemotherapeutic tolerance and improve immune defenses. Since childhood cancer is beginning to frequently show excellent outcome, the association of malnutrition with progressive disease strongly suggests investigation of the role of nutritional support.
在一组有骨转移或骨转移性疾病的患者中高达37.5%，在一组新诊断的腹部或盆腔肿瘤患者中为17.5%。在某些癌症中，如尤因肉瘤，其出现频率似乎比其他癌症，如骨肉瘤，更高。明显营养不良的诊断标准适用于癌症患儿。这种明显的营养不良可以通过静脉高营养（IVH）成功且安全地治疗。边缘性营养不良是一种可从临床行为推断出来的状态，尽管目前还无法客观诊断。早期数据表明，通过静脉高营养可以避免恶化为明显的营养不良。这种营养干预可能会增加化疗耐受性并改善免疫防御。由于儿童癌症开始经常显示出良好的预后，营养不良与疾病进展之间的关联强烈表明需要研究营养支持的作用。
