Koudstaal J, Braat D D, Bruinse H W, Naaktgeboren N, Vermeiden J P, Visser G H
Department of Obstetrics and Gynaecology, University Medical Centre, Utrecht, The Netherlands.
Hum Reprod. 2000 Aug;15(8):1819-25. doi: 10.1093/humrep/15.8.1819.
In singleton pregnancies after IVF a high rate of preterm deliveries and an increased rate of small-for-gestational age (SGA) children in comparison to the general parturient population have been reported. However, due to differences between IVF mothers and their peers who conceived naturally, careful selection of the control group is necessary to assess whether IVF pregnancies really carry increased risks of adverse outcome. In our study 307 IVF pregnancies were compared with 307 control pregnancies after elaborate matching for an extensive number of maternal characteristics, as well as for the hospital that provided the obstetric care. Four Dutch university hospitals contributed to the study. In cases with spontaneous onset of labour, gestational age at delivery was 3 days shorter in the IVF group (275 versus 278 days, P = 0.05). The proportion of SGA was higher in the IVF group (16.2 versus 7.9%, P < 0.001). The combination of these two results denotes a distinct difference between IVF and control pregnancies. Placental weight was comparable in both groups.
据报道，与一般产妇群体相比，体外受精（IVF）后的单胎妊娠早产率较高，小于胎龄（SGA）儿的发生率也有所增加。然而，由于IVF母亲与其自然受孕的同龄人之间存在差异，因此需要谨慎选择对照组，以评估IVF妊娠是否真的具有更高的不良结局风险。在我们的研究中，对307例IVF妊娠与307例对照妊娠进行了比较，在对大量母亲特征以及提供产科护理的医院进行精心匹配之后开展此项研究。四家荷兰大学医院参与了这项研究。在自然发动分娩的病例中，IVF组的分娩孕周短3天（275天对278天，P = 0.05）。IVF组中SGA的比例更高（16.2%对7.9%，P < 0.001）。这两个结果的结合表明IVF妊娠与对照妊娠之间存在明显差异。两组的胎盘重量相当。
