Department of Preventive Medicine, Keck School of Medicine at USC, 1441 Eastlake Avenue, MC-9175, Los Angeles, CA, 90089-9175, USA.
Department of Obstetrics and Gynecology, Keck School of Medicine at USC, Los Angeles, CA, USA.
J Assist Reprod Genet. 2018 Jun;35(6):943-952. doi: 10.1007/s10815-018-1173-x. Epub 2018 Apr 25.
To determine whether a history of conception by assisted reproductive technology (ART) is associated with occurrence of one or more imprinting disorders of either maternal or paternal origin.
We implemented a systematic review of scholarly literature followed by comprehensive meta-analysis to quantitatively synthesize data from reports relating to use of ART to occurrence of any imprinting disorder of humans, including Beckwith-Wiedemann (BWS), Angelman (AS), Prader-Willi (PWS), and Silver-Russell (SRS) syndromes, as well as transient neonatal diabetes mellitus (TNDB) and sporadic retinoblasoma (RB).
The systematic review identified 13 reports presenting unique data from 23 studies that related conception following ART to occurrence of imprinting disorders. Multiple studies of four disorder were identified, for which meta-analysis yielded the following summary estimates of associations with a history of ART: AS, summary odds ratio (sOR) = 4.7 (95% confidence interval (CI) 2.6-8.5, 4 studies); BWS, sOR = 5.8 (95% CI 3.1-11.1, 8 studies); PWS, sOR = 2.2 (95% CI 1.6-3.0, 6 studies); SRS, sOR = 11.3 (95% CI 4.5-28.5, 3 studies). Only one study reported on each of TNDB and RB.
Published data reveal positive associations between history of ART conception and each of four imprinting disorders. Reasons for these associations warrant further investigation.
确定辅助生殖技术（ART）受孕史是否与母体或父体来源的一种或多种印迹疾病的发生有关。
我们对学术文献进行了系统评价，然后进行了全面的荟萃分析，以定量综合与使用 ART 导致人类发生任何印迹疾病（包括 Beckwith-Wiedemann [BWS]、Angelman [AS]、Prader-Willi [PWS] 和 Silver-Russell [SRS] 综合征）、以及短暂性新生儿糖尿病（TNDB）和散发性视网膜母细胞瘤（RB）相关的报告中的数据。
系统评价确定了 13 份报告，这些报告提供了 23 项研究的独特数据，这些研究将 ART 受孕与印迹疾病的发生联系起来。确定了四项疾病的多项研究，对这些研究进行荟萃分析得出了与 ART 受孕史相关的关联的以下综合估计值：AS，汇总优势比（sOR）=4.7（95%置信区间（CI）2.6-8.5，4 项研究）；BWS，sOR=5.8（95% CI 3.1-11.1，8 项研究）；PWS，sOR=2.2（95% CI 1.6-3.0，6 项研究）；SRS，sOR=11.3（95% CI 4.5-28.5，3 项研究）。仅有一项研究报告了 TNDB 和 RB 的情况。
已发表的数据显示，ART 受孕史与四种印迹疾病中的每一种都存在正相关。这些关联的原因值得进一步研究。
