Ríos E, Heresi G, Arevalo M
Department of Pediatrics, Calvo Mackenna Children's Hospital, Santiago, Chile.
Am J Pediatr Hematol Oncol. 1991 Fall;13(3):296-9. doi: 10.1097/00043426-199123000-00008.
Three siblings with alloimmune neonatal neutropenia are presented. An immunoglobulin G (IgG) antineutrophil antibody specific for NA-2 antigen was demonstrated in maternal serum and in both of the three affected infants who were studied as neonates. The mother's neutrophils were negative for NA-2 antigen. The father and all four children, including the three known to be affected, had neutrophils that expressed NA-2 antigen. One patient studied sequentially demonstrated an inverse relationship between the antineutrophil antibody titer and the absolute neutrophil count. Exchange transfusions did not appear to benefit two of the infants.
本文报告了3例患有同种免疫性新生儿中性粒细胞减少症的兄弟姐妹。在母亲血清以及3例作为新生儿接受研究的患病婴儿中的2例体内，均检测到了一种针对NA-2抗原的免疫球蛋白G（IgG）抗中性粒细胞抗体。母亲的中性粒细胞对NA-2抗原呈阴性反应。父亲以及包括3例已知患病儿童在内的所有4个孩子的中性粒细胞均表达NA-2抗原。对1例患者进行的连续研究显示，抗中性粒细胞抗体滴度与中性粒细胞绝对计数之间呈负相关。换血疗法似乎对其中2例婴儿并无益处。
