Askonas B A
Acta Endocrinol Suppl (Copenh). 1975;194:117-32. doi: 10.1530/acta.0.080s0117.
Several aspects of synthesis and assembly of Ig molecules in small lymphocytes and in differentiated plasma cells are summarized. Some attempt has been made to analyse at the molecular level what happens on conversion of a lymphocyte to a mature cell secreting high levels of Ig. For this study LPS activation of murine B-lymphocytes into division and maturation served as a model system. A rapid rate of mitosis and high rate of H-mRNA synthesis appeared to precede the high levels of Ig production, suggesting a translational block on H-mRNA until the cell had organized its endoplasmic reticulum and matured. In vivo, with the exception of T-independent antigens, it is unlikely that B-cell maturationis an automatic sequel to division stimuli. We are largely ignorant in this area but possible regulatory signals which achieve a dissociation of B-cell division and maturation are discussed.
总结了小淋巴细胞和分化浆细胞中免疫球蛋白（Ig）分子合成与组装的几个方面。已尝试在分子水平分析淋巴细胞转化为分泌高水平Ig的成熟细胞时会发生什么。在本研究中，用脂多糖（LPS）激活小鼠B淋巴细胞使其分裂和成熟作为模型系统。在高水平Ig产生之前，有丝分裂的快速速率和H-信使核糖核酸（H-mRNA）合成的高速率似乎就已出现，这表明在细胞组织其内质网并成熟之前，H-mRNA存在翻译障碍。在体内，除了非T细胞依赖性抗原外，B细胞成熟不太可能是分裂刺激的自动结果。我们在这一领域很大程度上尚不清楚，但讨论了可能实现B细胞分裂与成熟解离的调节信号。
