DNA合成对于B淋巴细胞分化为分泌免疫球蛋白的浆细胞来说是必需的吗？

Is DNA synthesis a requisite for the differentiation of B lymphocytes into immunoglobulin-secreting plasma cells?

作者信息

Attallah A M, Yeatman T J, Noguchi P D, Petricciani J C

出版信息

Int Arch Allergy Appl Immunol. 1979;60(2):132-9. doi: 10.1159/000232334.

DOI:10.1159/000232334

Abstract

A great amount of conflicting evidence has been reported concerning the relationship between DNA synthesis and the differentiation of immunoglobulin-secreting cells. With the development of flow cytometry, it has become possible to analyze lymphocyte populations by making rapid and accurate measurements of cellular DNA content, and by estimating the fraction of cells that synthesize DNA. Application of these techniques to an in vitro culture system stimulated by the T-dependent sheep red blood cell antigen has allowed us to investigate cell division in populations of antibody-forming cells. DNA synthesis is apparently not a requisite for the differentiation of immunoglobulin-secreting cells.

摘要

关于DNA合成与免疫球蛋白分泌细胞分化之间的关系，已有大量相互矛盾的证据报道。随着流式细胞术的发展，通过快速准确地测量细胞DNA含量以及估计合成DNA的细胞比例来分析淋巴细胞群体已成为可能。将这些技术应用于由T细胞依赖性绵羊红细胞抗原刺激的体外培养系统，使我们能够研究抗体形成细胞群体中的细胞分裂。显然，DNA合成并非免疫球蛋白分泌细胞分化的必要条件。

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