Vankemmel M, Dell'Oste L, Kouame J
Chirurgie digestive, hôpital Huriez, Lille, France.
Ann Chir. 2000 Jan;125(1):50-6.
The aim of this retrospective study was to report the results, with a minimum 10-year follow-up, of highly selective portal decompression (HSPD) realized in order to prevent bleeding recurrences from esophageal or gastric varices in a series of 122 cirrhotic patients.
From January 1980 to February 1997, 122 patients (85 men and 37 women, mean age: 50.4 years) with liver cirrhosis stage A (n = 6), B (n = 50), C (n = 6) according to Child classification, were operated on for bleeding varices after a delay in 106 patients, on emergency in 16 patients. The HSPD included a double vascular ligature (splenic artery ligature in case of hypersplenism [n = 42] and high perigastric veins ligature) and a double tissular stapling (low esophagus transection and valvuloplasty). Other associated procedures were performed including cholecystendesis in 21 patients.
Perioperative mortality rate was 8% (n = 10). There was no anastomotic leakage but anastomotic stenosis in ten patients treated by dilatation. Three patients only out of 109 (2.5%) were lost for follow-up. Portocaval encephalopathy was not observed in any patient. Global survival rate was 60% at 5 years and 45% at 10 years. The mortality rate related to recurrent esophageal varice bleeding was 11% and related to hepatocellular failure 18.5% during the entire follow-up.
HSPD appears to be the best procedure in cirrhotic patients for the prevention of recurrent esophageal varice bleeding. Preservation of portal pressure within the cirrhotic liver (whereas it is reduced in varices) contributes to the preservation of hepatocellular function, avoiding portocaval encephalopathy.
本回顾性研究的目的是报告在一系列122例肝硬化患者中为预防食管或胃静脉曲张出血复发而实施的高选择性门静脉减压术(HSPD)的结果,随访时间至少为10年。
1980年1月至1997年2月,122例患者(85例男性和37例女性,平均年龄:50.4岁),根据Child分级为A期(n = 6)、B期(n = 50)、C期(n = 6)的肝硬化患者,106例患者在出血延迟后接受静脉曲张手术,16例患者接受急诊手术。HSPD包括双重血管结扎(脾功能亢进时结扎脾动脉[n = 42]和高位胃周静脉结扎)和双重组织吻合器吻合(低位食管横断和瓣膜成形术)。还进行了其他相关手术,包括21例患者的胆囊切除术。
围手术期死亡率为8%(n = 10)。无吻合口漏,但10例接受扩张治疗的患者出现吻合口狭窄。109例患者中仅有3例(2.5%)失访。未观察到任何患者发生门体性脑病。5年总生存率为60%,10年为45%。在整个随访期间,与食管静脉曲张出血复发相关的死亡率为11%,与肝细胞衰竭相关的死亡率为18.5%。
HSPD似乎是肝硬化患者预防食管静脉曲张出血复发的最佳手术方法。保留肝硬化肝脏内的门静脉压力(而在静脉曲张中门静脉压力降低)有助于保留肝细胞功能,避免门体性脑病。