Hinman A R, Fraser D W, Douglas R G, Bowen G S, Kraus A L, Winkler W G, Rhodes W W
Am J Epidemiol. 1975 Feb;101(2):103-10. doi: 10.1093/oxfordjournals.aje.a112076.
An outbreak of lymphocytic choriomeningitis (LCM) virus infections occurred in Medical Center personnel at the University of Rochester in 1972-1973. A total of 48 infections was discovered, 31 in staff of the radiation therapy area, 12 in the staff of the Vivarium facility, and 5 in other individuals who worked in the Medical Center. Twenty-one of the infections were associated with recent febrile illness with myalgia. Epidemiologic and virologic studies indicated that the source of the infection was Syrian hamsters which were used in tumor research; the tumor cell lines themselves were shown to be contaminated with LCM virus and probably represented the original source of contamination of the Rochester facility. Infection occurred not only through direct contact with infected animals but also from mere presence in the room where the animals were held. This outbreak emphasizes the need for restricting access to animal quarters and for surveillance of hamsters and tumor cell lines and indicate the necessity of separating animal facilities from patient-care facilities.
1972年至1973年，罗切斯特大学医学中心的工作人员中爆发了淋巴细胞性脉络丛脑膜炎（LCM）病毒感染。共发现48例感染病例，其中放疗区工作人员31例，实验动物饲养设施工作人员12例，医学中心其他工作人员5例。21例感染与近期伴有肌痛的发热性疾病有关。流行病学和病毒学研究表明，感染源是用于肿瘤研究的叙利亚仓鼠；肿瘤细胞系本身被证明受到LCM病毒污染，可能是罗切斯特设施最初的污染源。感染不仅通过直接接触受感染动物发生，也可因仅仅身处饲养动物的房间而感染。此次疫情强调了限制进入动物饲养区以及对仓鼠和肿瘤细胞系进行监测的必要性，并表明将动物设施与患者护理设施分开的必要性。
