Rahme L G, Ausubel F M, Cao H, Drenkard E, Goumnerov B C, Lau G W, Mahajan-Miklos S, Plotnikova J, Tan M W, Tsongalis J, Walendziewicz C L, Tompkins R G
Department of Surgery, Harvard Medical School, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8815-21. doi: 10.1073/pnas.97.16.8815.
By exploiting the ability of Pseudomonas aeruginosa to infect a variety of vertebrate and nonvertebrate hosts, we have developed model systems that use plants and nematodes as adjuncts to mammalian models to help elucidate the molecular basis of P. aeruginosa pathogenesis. Our studies reveal a remarkable degree of conservation in the virulence mechanisms used by P. aeruginosa to infect hosts of divergent evolutionary origins.
通过利用铜绿假单胞菌感染多种脊椎动物和非脊椎动物宿主的能力,我们开发了一些模型系统,这些系统利用植物和线虫作为哺乳动物模型的辅助手段,以帮助阐明铜绿假单胞菌致病机制的分子基础。我们的研究揭示,铜绿假单胞菌用于感染进化起源不同的宿主的毒力机制存在显著程度的保守性。