Watanabe S, Ishino H, Otsuki S
Arch Gen Psychiatry. 1975 May;32(5):659-68. doi: 10.1001/archpsyc.1975.01760230125010.
The effect of lithium carbonate therapy on patients with depression is still unconfirmed. Our past studies have shown a favorable response to the drug in patients with depression of mild or moderate severity. Therefore, we performed a controlled double-blind study of lithium carbonate and imipramine hydrochloride in 64 patients with depression. No significant differences were noted in the overall therapeutic response, depression scale scores, or clinical effects between the two drug groups.
碳酸锂疗法对抑郁症患者的疗效仍未得到证实。我们过去的研究表明，该药物对轻度或中度抑郁症患者有良好反应。因此，我们对64名抑郁症患者进行了碳酸锂和盐酸丙咪嗪的对照双盲研究。两个药物组在总体治疗反应、抑郁量表评分或临床效果方面均未发现显著差异。
