天然存在的双链RNA与免疫反应。对空斑形成细胞和抗体形成的影响。
Naturally occurring double-stranded RNA and immune responses. Effects on plaque-forming cells and antibody formation.
作者信息
Cunnington P G, Naysmith J D
出版信息
Immunology. 1975 Mar;28(3):451-68.
Abstract
A highly purified preparation of double-stranded RNA, obtained from virus-like particles in Penicillium cultures, was found to affert humoral immune responses in mice differentially depending on its time of administration in realtion to antigen. Double-stranded RNA administered with antigen, or a few hours after antigen, produced a variable degree of enhancement of plaque-forming cell numbers or agglutinating antibody levels depending on the antigen involved. Administration of double-stranded RNA 24 hours before antigen invariably produced a suppressed response. In mice which were either specifically hyporesponsive (tolerant) or non-specifically hyporesponsive (due to age or immunosuppressive drugs) double-stranded RNA administered with antigen resulted in a nearly normal immune response.
摘要
从青霉菌培养物中的病毒样颗粒获得的高度纯化的双链RNA制剂，被发现根据其与抗原给药时间的不同，对小鼠的体液免疫反应有不同影响。与抗原同时给药或在抗原给药后数小时给药的双链RNA，根据所涉及的抗原不同，会使空斑形成细胞数量或凝集抗体水平产生不同程度的增强。在抗原给药前24小时给予双链RNA总是会产生抑制反应。在特异性低反应（耐受）或非特异性低反应（由于年龄或免疫抑制药物）的小鼠中，与抗原一起给予双链RNA会导致几乎正常的免疫反应。
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