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1
(dA-dT) dependent inactivation of the DNA template properties by interaction with netropsin and distamycin A.通过与纺锤菌素和偏端霉素A相互作用，（dA-dT）依赖性地使DNA模板特性失活。
Nucleic Acids Res. 1975 Mar;2(3):391-404. doi: 10.1093/nar/2.3.391.
2
Conformation dependent binding of netropsin and distamycin to DNA and DNA model polymers.纺锤菌素和偏端霉素与DNA及DNA模型聚合物的构象依赖性结合
Nucleic Acids Res. 1974 Mar;1(3):503-30. doi: 10.1093/nar/1.3.503.
3
Binding of nonintercalative antitumor drugs to DNA-polymers: structural effects of bisquaternary ammonium heterocycles.非嵌入型抗肿瘤药物与DNA聚合物的结合：双季铵杂环的结构效应
J Biomol Struct Dyn. 1987 Apr;4(5):813-31. doi: 10.1080/07391102.1987.10507680.
4
Influence of nucleotide sequence on dA.dT-specific binding of Netropsin to double stranded DNA.核苷酸序列对纺锤菌素与双链DNA的dA.dT特异性结合的影响。
Nucleic Acids Res. 1979 Jun 25;6(8):2831-7. doi: 10.1093/nar/6.8.2831.
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Formation of poly (dA)-poly(dT) by Escherichia coli DNA polymerase in the presence of anthracycline antibiotics.在蒽环类抗生素存在的情况下，大肠杆菌DNA聚合酶形成聚（dA）-聚（dT）。
Biochim Biophys Acta. 1972 Aug 25;277(2):269-75. doi: 10.1016/0005-2787(72)90407-8.
6
Z-DNA and other non-B-DNA structures are reversed to B-DNA by interaction with netropsin.Z-DNA和其他非B-DNA结构通过与纺锤菌素相互作用而转变为B-DNA。
FEBS Lett. 1983 Apr 5;154(1):156-60. doi: 10.1016/0014-5793(83)80894-1.
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Interaction of nucleic acids with a non-intercalative anti-leukemic compound containing bisquarternary heterocycles.核酸与一种含双季铵杂环的非嵌入性抗白血病化合物的相互作用。
Biochim Biophys Acta. 1984 May 15;782(1):41-8. doi: 10.1016/0167-4781(84)90104-0.
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Two binding modes of netropsin are involved in the complex formation with poly(dA-dT).poly(dA-dT) and other alternating DNA duplex polymers.纺锤菌素与聚（dA-dT）·聚（dA-dT）及其他交替DNA双链聚合物形成复合物时涉及两种结合模式。
J Biomol Struct Dyn. 1985 Feb;2(4):721-36. doi: 10.1080/07391102.1985.10506319.
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Comparative ability of RNA and DNA to prime DNA synthesis in vitro: role of sequence, sugar, and structure of template-primer.RNA和DNA在体外引发DNA合成的比较能力：模板引物的序列、糖和结构的作用
Biochemistry. 1975 Apr 8;14(7):1412-25. doi: 10.1021/bi00678a011.
10
Natural and synthetic double-stranded DNA binding studies of macrocyclic tetraamine zinc(II) complexes appended with polyaromatic groups.带有多芳基基团的大环四胺锌（II）配合物的天然和合成双链DNA结合研究。
J Biol Inorg Chem. 1999 Aug;4(4):431-40. doi: 10.1007/s007750050329.

引用本文的文献

1
Solution structure of a highly stable DNA duplex conjugated to a minor groove binder.与小沟结合剂共轭的高度稳定DNA双链体的溶液结构
Nucleic Acids Res. 1998 Feb 1;26(3):831-8. doi: 10.1093/nar/26.3.831.
2
The molecular electrostatic potential and steric accessibility of poly (dI.dC). Comparison with poly (dG.dC).聚（dI.dC）的分子静电势和空间可及性。与聚（dG.dC）的比较。
Nucleic Acids Res. 1981 Dec 21;9(24):7041-51. doi: 10.1093/nar/9.24.7041.
3
The molecular electrostatic potential and steric accessibility of poly (dA-dT). poly (dA-dT) in various conformations: B-DNA, D-DNA and 'alternating-B' DNA.聚（dA-dT）·聚（dA-dT）在不同构象（B-DNA、D-DNA和“交替B”DNA）下的分子静电势和空间可及性。
Nucleic Acids Res. 1981 Dec 11;9(23):6539-52. doi: 10.1093/nar/9.23.6539.
4
Protection of (dA.dT) cluster regions in the DNAase I cleavage of DNA by specific interaction with netropsin.通过与纺锤菌素的特异性相互作用保护DNAase I切割DNA时的(dA.dT)簇区域。
Nucleic Acids Res. 1980 Jul 11;8(13):2999-3010. doi: 10.1093/nar/8.13.2999.
5
The molecular origin of DNA-drug specificity in netropsin and distamycin.纺锤菌素和偏端霉素中DNA-药物特异性的分子起源。
Proc Natl Acad Sci U S A. 1985 Mar;82(5):1376-80. doi: 10.1073/pnas.82.5.1376.
6
The formation of A-DNA in NaDNA films is suppressed by netropsin.纳他霉素可抑制NaDNA膜中A-DNA的形成。
Nucleic Acids Res. 1992 Mar 25;20(6):1223-8. doi: 10.1093/nar/20.6.1223.
7
Duplex structure formation between oligo(dA)'s and oligo(dT)'s generated by thymine-specific interaction with netropsin.由嗜中性霉素与胸腺嘧啶的特异性相互作用所产生的寡聚（dA）与寡聚（dT）之间的双链结构形成
Nucleic Acids Res. 1976 Jun;3(6):1521-32. doi: 10.1093/nar/3.6.1521.
8
Specific interactions of distamycin A and its analogs with (A-T) rich and (G-C) rich duplex regions of DNA and deoxypolynucleotides.偏端霉素A及其类似物与DNA和脱氧多核苷酸富含（A-T）及富含（G-C）的双链区域的特异性相互作用。
Nucleic Acids Res. 1977 Aug;4(8):2655-70. doi: 10.1093/nar/4.8.2655.

本文引用的文献

1
Effect of Distamycin A on the template activity of DNA in a DNA polymerase system.偏端霉素A对DNA聚合酶系统中DNA模板活性的影响。
FEBS Lett. 1969 Aug;4(4):355-357. doi: 10.1016/0014-5793(69)80275-9.
2
Preferential binding of E. coli RNA-polymerase to A-T rich sequences of bacteriophage lambda DNA.大肠杆菌RNA聚合酶与噬菌体λ DNA富含A - T序列的优先结合。
FEBS Lett. 1971 Jan 30;12(5):253-256. doi: 10.1016/0014-5793(71)80190-4.
3
Conformation dependent binding of netropsin and distamycin to DNA and DNA model polymers.纺锤菌素和偏端霉素与DNA及DNA模型聚合物的构象依赖性结合
Nucleic Acids Res. 1974 Mar;1(3):503-30. doi: 10.1093/nar/1.3.503.
4
Purification and properties of deoxyribonucleic acid polymerase from Micrococcus lysodeikticus.溶壁微球菌脱氧核糖核酸聚合酶的纯化及性质
J Biol Chem. 1966 May 10;241(9):2035-41.
5
Preferential binding of RNA polymerase to the thymidylic acid-rich fragments obtained from bacteriophage fl DNA.RNA聚合酶与从噬菌体fl DNA获得的富含胸苷酸的片段的优先结合。
J Biochem. 1970 Dec;68(6):881-4. doi: 10.1093/oxfordjournals.jbchem.a129427.
6
Influence of netropsin and distamycin A on the secondary structure and template activity of DNA.纺锤菌素和偏端霉素A对DNA二级结构及模板活性的影响。
Eur J Biochem. 1971 Jul 29;21(2):269-78. doi: 10.1111/j.1432-1033.1971.tb01466.x.
7
Binding of netropsin to DNA and synthetic polynucleotides.纺锤菌素与DNA及合成多核苷酸的结合。
Mol Biol Rep. 1974 Mar;1(6):337-42. doi: 10.1007/BF00309567.
8
Studies on the effect of distamycin A on the DNA dependent RNA polymerase system.关于偏端霉素A对依赖DNA的RNA聚合酶系统作用的研究。
Biochem Biophys Res Commun. 1971 May 7;43(3):617-24. doi: 10.1016/0006-291x(71)90659-0.
9
Distamycin: an inhibitor of DNA-dependent nucleic acid synthesis.偏端霉素：一种DNA依赖性核酸合成抑制剂。
Chem Biol Interact. 1974 Mar;8(3):183-92. doi: 10.1016/0009-2797(74)90040-4.

通过与纺锤菌素和偏端霉素A相互作用，（dA-dT）依赖性地使DNA模板特性失活。

(dA-dT) dependent inactivation of the DNA template properties by interaction with netropsin and distamycin A.

作者信息

Wähnert U, Zimmer O, Luck G, Pitra O

出版信息

Nucleic Acids Res. 1975 Mar;2(3):391-404. doi: 10.1093/nar/2.3.391.

DOI:10.1093/nar/2.3.391
PMID:1093141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342845/
Abstract

The inhibitory effect of the polypeptide antibiotics netropsin and distamycin A on DNA dependent nucleic acid synthesis has been shown to be related to the base composition of the template DNA. A number of natural DNA's of quite different dA-dT content as well as poly (dI-dC)-poly (dI-dC), poly (dA-dT)-poly (dA-dT), poly (dA) - poly (dT) and poly (dG) - poly (dC) has been studied as templates in DNA and in part in RNA polymerase reaction. The highest binding efficiency of netropsin existing for (dA-dT) - containing DNA polymers and the less pronounced interaction with the (dI-dC)-containing polymer shown by the melting and CD spectrral behaviour of the complexes are entirely reflected in the template inactivation. The same is evident for distamycin A. However, in contrast to netropsin the antibiotic distamycin A exhibits some binding tendency to poly (dG) - poly (dC). Binding effects of a netropsin derivative to DNA and (dA-dT) -containing polymers suggest the importance of hydrogen bonds of the peptide groups in the complex formation.

摘要

多杀菌素和偏端霉素A这两种多肽抗生素对依赖DNA的核酸合成的抑制作用已被证明与模板DNA的碱基组成有关。人们研究了许多dA-dT含量差异很大的天然DNA以及聚（dI-dC）-聚（dI-dC）、聚（dA-dT）-聚（dA-dT）、聚（dA）-聚（dT）和聚（dG）-聚（dC），将其作为DNA以及部分RNA聚合酶反应中的模板。多杀菌素对含（dA-dT）的DNA聚合物具有最高的结合效率，而通过复合物的熔解和圆二色光谱行为显示其与含（dI-dC）聚合物的相互作用较弱，这在模板失活中得到了充分体现。偏端霉素A也是如此。然而，与多杀菌素不同的是，抗生素偏端霉素A对聚（dG）-聚（dC）表现出一定的结合倾向。多杀菌素衍生物与DNA和含（dA-dT）聚合物的结合效应表明肽基团的氢键在复合物形成中具有重要作用。