偏端霉素A及其类似物与DNA和脱氧多核苷酸富含（A-T）及富含（G-C）的双链区域的特异性相互作用。
Specific interactions of distamycin A and its analogs with (A-T) rich and (G-C) rich duplex regions of DNA and deoxypolynucleotides.
作者信息
Luck G, Zimmer C, Reinert K E, Arcamone F
出版信息
Nucleic Acids Res. 1977 Aug;4(8):2655-70. doi: 10.1093/nar/4.8.2655.
Abstract
The specific interaction of distamycin A and analogs with DNA's and synthetic deoxypolynucleotide duplexes were studied in detail by means of circular dichroism and the data were analyzed together with viscosity results of several natural DNA's. At low ligand to nucleotide ratio the previously reported specific binding to (A-T) pairs of DNA is verified by a highly favoured interaction with (A-T)-enriched segments of distamycins containing four and five methylpyrrole carboxamide units. At higher distamycin concentration a second specific binding to (G-C) pairs most probably through hydrogen bonding is established. Viscometric results suggest a distamycin-induced local bending of the helix and could support the idea of a preferential alignment of the ligand molecule along only one strand in the groove which differs from the netropsin interaction mechanism. The possibility of an overlapping binding of the oligopeptides in the small groove is discussed.
摘要
通过圆二色性详细研究了放线菌素A及其类似物与DNA和合成脱氧多核苷酸双链体的特异性相互作用，并将这些数据与几种天然DNA的粘度结果一起进行了分析。在低配体与核苷酸比例下，先前报道的与DNA的（A-T）对的特异性结合通过与含有四个和五个甲基吡咯甲酰胺单元的放线菌素的富含（A-T）的片段的高度有利相互作用得到证实。在较高的放线菌素浓度下，很可能通过氢键与（G-C）对建立了第二种特异性结合。粘度结果表明放线菌素诱导螺旋的局部弯曲，并可能支持配体分子仅沿着沟中的一条链优先排列的观点，这与纺锤菌素的相互作用机制不同。讨论了寡肽在小沟中重叠结合的可能性。
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Specific interactions of distamycin A and its analogs with (A-T) rich and (G-C) rich duplex regions of DNA and deoxypolynucleotides.偏端霉素A及其类似物与DNA和脱氧多核苷酸富含（A-T）及富含（G-C）的双链区域的特异性相互作用。
Nucleic Acids Res. 1977 Aug;4(8):2655-70. doi: 10.1093/nar/4.8.2655.
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Selective inhibition of the multiplication of phage Tl in E. coli K12.噬菌体T1在大肠杆菌K12中增殖的选择性抑制
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