遗传性无脾及成年脾切除小鼠骨髓 - 胸腺细胞协同作用的改变
Alteration of bone marrow-thymus cell synergism in hereditary asplenic and adult splenctomiced mice.
作者信息
Wargon L B, Lozzio B B, Wust C J
出版信息
Proc Soc Exp Biol Med. 1975 Mar;148(3):925-8. doi: 10.3181/00379727-148-38661.
PMID:1093196
Abstract
The cooperation betweeen bone marrow (B) and thymus (T) cells was markedly impaired in mice with congenital asplenia. The deficiency of IgM producers could not be corrected by neotal transplantation of spleen cells. The use of T and B cells from splenectomized donors resulted in a marked shift from 19S to 7S antibody forming cells.
摘要
先天性无脾小鼠的骨髓（B）细胞与胸腺（T）细胞之间的合作明显受损。脾脏细胞的新生移植无法纠正IgM产生细胞的缺乏。使用脾切除供体的T细胞和B细胞导致抗体形成细胞从19S显著转变为7S。
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