Traeden U I, Holm L, Sandström B, Andersen P K, Jarden M
Institute of Public Health, Department of Social Medicine and Psychosocial Health, University of Copenhagen, Denmark.
Public Health Nutr. 1998 Dec;1(4):273-81. doi: 10.1079/phn19980044.
To evaluate the effect of a dietary treatment programme on blood cholesterol concentration in hypercholesterolaemic patients in general practice and to analyse subjectively experienced side-effects.
A 1-year parallel trial comparing a new treatment programme with conventional treatment.
General practitioners in Roskilde county, Denmark.
355 men and women, aged 20-60 years, with a persistent blood cholesterol concentration above age- and gender-specific cut-off points (265 in an intervention group and 90 in a control group).
A treatment strategy based on collaboration between doctor and dietitian using individual dietary advice and feedback from measured biological parameters.
Serum lipids, body weight, blood pressure, dietary behaviour, health parameters, quality of life parameters and acceptance by patients and general practitioners.
Total blood cholesterol concentration decreased by 14% (1.07 mmol l(-1), P < 0.0001) in 159 patients in the intervention group, not having any lipid altering drug during treatment, in addition to 3% from screening to start of treatment. In 65 patients in the control group, without any lipid altering drug, the reduction of cholesterol concentration was 4% (0.27 mmol l(-1), P < 0.01; intervention vs. control P < 0.001). In the intervention group overweight subjects (body mass index > 30) reduced body weight by 6% (P < 0.0001). Systolic blood pressure was reduced by 11% (P < 0.0001) and diastolic blood pressure by 10% (P < 0.0001) and 19% (P < 0.003) for intervals 90-110 mmHg and > 110 mmHg, respectively. Risk score decreased and self-assessed health, physical and psychological well-being improved.
The treatment strategy tested proved to be efficient, without side-effects and well accepted by patients and general practitioners. The results strongly suggest that hypercholesterolaemia can efficiently be treated non-pharmacologically in general practice.
评估一项饮食治疗方案对全科医疗中高胆固醇血症患者血液胆固醇浓度的影响，并分析主观感受到的副作用。
一项为期1年的平行试验，将一种新的治疗方案与传统治疗进行比较。
丹麦罗斯基勒郡的全科医生。
355名年龄在20 - 60岁之间的男性和女性，其血液胆固醇浓度持续高于年龄和性别特异性切点（干预组265例，对照组90例）。
一种基于医生和营养师合作的治疗策略，采用个性化饮食建议以及根据测量的生物学参数提供反馈。
血脂、体重、血压、饮食行为、健康参数、生活质量参数以及患者和全科医生的接受程度。
干预组159例在治疗期间未服用任何调脂药物的患者，其总血胆固醇浓度除筛查至治疗开始阶段降低3%外，又降低了14%（1.07 mmol·l⁻¹，P < 0.0001）。对照组65例未服用任何调脂药物的患者，胆固醇浓度降低了4%（0.27 mmol·l⁻¹，P < 0.01；干预组与对照组比较，P < 0.001）。干预组超重受试者（体重指数>30）体重降低了6%（P < 0.0001）。收缩压分别降低了11%（P < 0.0001），舒张压在90 - 110 mmHg和>110 mmHg区间分别降低了10%（P < 0.0001）和19%（P < 0.003）。风险评分降低，自我评估的健康状况、身体和心理健康状况得到改善。
所测试的治疗策略被证明是有效的，没有副作用，并且患者和全科医生都能很好地接受。结果强烈表明，在全科医疗中，高胆固醇血症可以通过非药物方法有效治疗。
