Fornara C, Cursi M, Roveri L, Minicucci F, Locatelli T, Comi G
Department of Neurophysiology, IRCCS San Raffaele, Milan, Italy.
Ital J Neurol Sci. 1998 Aug;19(4):211-6. doi: 10.1007/BF02427603.
The electroencephalographic modifications that occur during the course of Alzheimer's disease are characterised by an increase in the potential of low frequency bands, a diminution in the potential of alpha activity, and a change in the topographical distribution of the potential of all band frequencies. In this study, the fast Fourier transform (FFT) approximation was used to characterise modifications in the electroencephalogram location or orientation of the source of the dipole equivalent of the delta, theta, alpha1, alpha2, beta1 and beta2 frequencies in 20 with patients with Alzheimer's disease and in a control group of 20 age-matched subjects. A statistical (t-test) comparison of the two groups revealed a significant change in the location of the dipolar source along the vertical axis in 18 (90%) of the patients; this change involved all the frequency bands. There was also a significant movement of the dipolar source of the alpha1 band towards the anterior regions. In addition, the control group showed that there was a significant correlation between age and a more surface expression of the source of the delta, theta, alpha1 and beta1 bands.
阿尔茨海默病病程中出现的脑电图改变的特征是低频波段电位增加、α波活动电位降低以及所有频段电位的地形分布变化。在本研究中，使用快速傅里叶变换（FFT）近似法来表征20例阿尔茨海默病患者和20例年龄匹配的对照组受试者中δ、θ、α1、α2、β1和β2频率等效偶极子源在脑电图中的位置或方向的改变。两组的统计学（t检验）比较显示，18例（90%）患者的偶极源沿垂直轴的位置有显著变化；这种变化涉及所有频段。α1频段的偶极源也显著向前部区域移动。此外，对照组显示年龄与δ、θ、α1和β1频段源的更浅表表达之间存在显著相关性。
