de Tommaso M, Sciruicchio V, Bellotti R, Guido M, Sasanelli G, Specchio L M, Puca F
1st Neurological Clinic, Department of Neurological and Psychiatric Sciences, Policlinico, University of Bari, Italy.
Ital J Neurol Sci. 1999 Feb;20(1):23-8. doi: 10.1007/s100720050006.
The aim of this study was to discriminate migraine patients (MWoA) from tension-type headache (TTH) patients and normals in order to confirm that the photic driving response in the medium frequency range is a marker of migraine and to test the hypothesis that MWoA and TTH are separate disorders based on electrophysiological pattern. We recruited 120 MWoA patients, 64 TTH patients, and 51 healthy controls without any history of headache or of migraine inheritance, according to International Headache Society (IHS) criteria. The classification method was discriminant analysis using both linear discriminant analysis with a stepwise selection of predictors and an artificial neural network classifier (NNs). The mean amplitude of the first harmonic elicited by flash stimulation in the 15-27 Hz range was significantly increased over Fp1, C3, C4, P4, O2, and O1 electrodes in MWoA and TTH patients in comparison with normal subjects. Using both classification methods, only the control subjects were correctly distinguished. When only the patient groups were matched, no significant difference was detectable. The increased brain response to visual stimulation detected in both migraine and TTH suggests a common neuronal dysfunction in the two headache subtypes.
本研究的目的是区分偏头痛患者（无先兆偏头痛，MWoA）与紧张型头痛（TTH）患者及正常人群，以确认中频范围内的光驱动反应是偏头痛的一个标志物，并基于电生理模式检验MWoA和TTH是不同疾病的假设。我们根据国际头痛协会（IHS）标准招募了120例MWoA患者、64例TTH患者和51名无头痛病史或偏头痛遗传史的健康对照者。分类方法是使用具有预测因子逐步选择的线性判别分析和人工神经网络分类器（NNs）进行判别分析。与正常受试者相比，MWoA和TTH患者在15 - 27 Hz范围内由闪光刺激诱发的一次谐波平均振幅在Fp1、C3、C4、P4、O2和O1电极上显著增加。使用两种分类方法时，只有对照组被正确区分。当仅对患者组进行匹配时，未检测到显著差异。在偏头痛和TTH中均检测到的对视觉刺激的脑反应增加表明这两种头痛亚型存在共同的神经元功能障碍。
