Ramos-Alvarez M, Miller B H, Jackson J E, Schwarz A J, Bessudo L
Am J Dis Child. 1975 Apr;129(4):474-7. doi: 10.1001/archpedi.1975.02120410054016.
The effects of simultaneous administration of Schwarz-strain measles virus vaccine and Cendehill-strain rubella virus vaccine as a single bivalent injection was evaluated in 346 children susceptible to both diseases. With placebo and monovalent controls, four bivalent preparations were used in a double-blind protocol to determine the effects of variations in the concentration of one or both components. No unusual reactions occurred and simultaneous administration did not enhance clinical reactivity. For measles, the seroconversion rate was 97% for monovalent vaccine and 97% to 100% (average 98%) for bivalent vaccines. For rubella, the rate was 100% for monovalent vaccine and 94% to 100% (average 99%) for bivalent vaccines. Thus, the vaccines were as safe and effective when given together as when given separately.
在346名对两种疾病均易感的儿童中，评估了将施瓦茨株麻疹病毒疫苗和森德希尔株风疹病毒疫苗作为单一二价注射剂同时接种的效果。采用安慰剂和单价对照，按照双盲方案使用了四种二价制剂，以确定一种或两种成分浓度变化的影响。未发生异常反应，同时接种并未增强临床反应性。对于麻疹，单价疫苗的血清转化率为97%，二价疫苗的血清转化率为97%至100%（平均98%）。对于风疹，单价疫苗的血清转化率为100%，二价疫苗的血清转化率为94%至100%（平均99%）。因此，两种疫苗同时接种时与单独接种时一样安全有效。
