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Clinical evaluation of a new measles-mumps-rubella trivalent vaccine.

作者信息

Schwarz A J, Jackson J E, Ehrenkranz N J, Ventura A, Schiff G M, Walters V W

出版信息

Am J Dis Child. 1975 Dec;129(12):1408-12. doi: 10.1001/archpedi.1975.02120490026008.

DOI:10.1001/archpedi.1975.02120490026008
PMID:128287
Abstract

In a series of clinical studies of a combined measles (Schwarz strain), mumps (Jeryl Lynn strain), and rubella (Cendehill strain) vaccine, 1,481 children received the vaccine or a placebo. The vaccine did not cause any significant reactions. The frequencies of mild, transient fever or rash or both in triple-susceptible vaccinees were similar to those that follow use of Schwarz strain measles vaccine alone. Measles, mumps, and rubella seroconversion rates in triple-susceptible vaccinees ranged from 95% to 100%. Geometric mean antibody titers were as high as those that usually result from use of these same virus strains as monovalent vaccines.

摘要

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