在多米尼加共和国对一种新型麻疹-腮腺炎-风疹联合活病毒疫苗进行的临床评估。
Clinical evaluation of a new measles-mumps-rubella combined live virus vaccine in the Dominican Republic.
作者信息
Ehrenkranz N J, Ventura A K, Medler E M, Jackson J E, Kenny M T
出版信息
Bull World Health Organ. 1975;52(1):81-5.
Abstract
Over 900 children were enrolled in a double-blind placebo-controlled clinical study of measles (Schwarz strain), mumps (Jeryl Lynn strain), and rubella (Cendehill strain) trivalent vaccine. The trivalent vaccine caused about the same degree of reactivity as is generally associated with the Schwarz strain measles vaccine. Paired sera from triplesusceptible vaccinees had seroconversion rates of 99% for measles, 94% for mumps, and 93% for rubella. The results of this study show that this trivalent vaccine is as well tolerated and as effective as its component vaccines.
摘要
900多名儿童参与了一项关于麻疹（施瓦茨株）、腮腺炎（杰里尔·林恩株）和风疹（森德希尔株）三价疫苗的双盲安慰剂对照临床研究。该三价疫苗引起的反应程度与施瓦茨株麻疹疫苗通常引起的反应程度大致相同。来自三联易感疫苗接种者的配对血清麻疹血清转化率为99%，腮腺炎为94%，风疹为93%。这项研究结果表明，这种三价疫苗的耐受性和有效性与各组分疫苗相当。
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