Hall A P, Doberstyn E B, Nanokorn A, Sonkom P
Br Med J. 1975 Apr 5;2(5961):12-4. doi: 10.1136/bmj.2.5961.12.
Clindamycin, a semi-synthetic antibiotic of the lincomycin family, at a dose of 450 mg eight-hourly for three days in adults cured five out of 10 patients moderately ill with chloroquine-resistant falciparum malaria. Combination therapy with full-dose quinine and clindamycin for three days cured all four patients so treated who were followed up, and with half dosage three out of five patients were cured. Both combinations, however, caused upper gastrointestinal toxicity and appeared to potentiate both toxicity and possibly antimalarial efficacy. Colitis due to clindamycin was not observed. Sequential therapy was not toxic and could be useful in patients who have relapsed after more conventional treatment.
克林霉素是林可霉素家族的一种半合成抗生素，在成人中以每八小时450毫克的剂量服用三天，治愈了10例中度氯喹耐药恶性疟患者中的5例。全剂量奎宁与克林霉素联合治疗三天，对所有接受随访的4例患者均有治愈效果，半剂量治疗时，5例患者中有3例被治愈。然而，这两种联合用药均导致上消化道毒性，且似乎会增强毒性以及可能的抗疟疗效。未观察到克林霉素引起的结肠炎。序贯疗法无毒性，对于经更传统治疗后复发的患者可能有用。
