SaiRam M, Ilavazhagan G, Sharma S K, Dhanraj S A, Suresh B, Parida M M, Jana A M, Devendra K, Selvamurthy W
Defence Institute of Physiology and Allied Sciences, Ministry of Defence, Timarpur, -1 10054, Delhi, India.
J Ethnopharmacol. 2000 Aug;71(3):377-82. doi: 10.1016/s0378-8741(99)00211-1.
Efficacy of NIM-76, a spermicidal fraction from neem oil, was investigated for its antimicrobial action against certain bacteria, fungi and Polio virus as compared to whole neem oil. The NIM-76 preparation showed stronger anti-microbial activity than the whole neem oil. It inhibited growth of various pathogens tested including Escherichia coli and Kleibsiella pneumoniae which were not affected by the whole neem oil. NIM-76 also exhibited antifungal activity against Candida albicans and antiviral activity against Polio virus replication in vero cell lines. It also protected mice from systemic candidiasis as revealed by enhanced % survival and reduced colony forming units of C. albicans in various tissues. This shows that NIM-76 has a potent broad spectrum anti-microbial activity.
研究了印楝油中的杀精成分NIM-76与全印楝油相比，对某些细菌、真菌和脊髓灰质炎病毒的抗菌作用。NIM-76制剂显示出比全印楝油更强的抗菌活性。它抑制了包括大肠杆菌和肺炎克雷伯菌在内的各种受试病原体的生长，而全印楝油对这些病原体没有影响。NIM-76还对白色念珠菌表现出抗真菌活性，并对脊髓灰质炎病毒在 vero 细胞系中的复制表现出抗病毒活性。如在各种组织中白色念珠菌的存活率提高和菌落形成单位减少所显示的那样，它还保护小鼠免受全身性念珠菌病的侵害。这表明NIM-76具有强大的广谱抗菌活性。
