Balcerska A, Stachowicz-Stencel T, Lysiak-Szydłowska W
Kliniki Pediatrii, Hematologii, Onkologii i Endokrynologii Akademii Medycznej w Gdańsku.
Wiad Lek. 2000;53(3-4):128-33.
The decreased ability to remove free radicals from organism is one of the factors which furthers the development of neoplastic process. Enzymes and substrates which can remove free radicals from organism from antioxidant barrier. The appreciation of some elements of antioxidant organism barrier in children with neoplastic disease was the study's purpose. We examined 100 children in the age from 6 months to 16 years (60 patients with malignant solid tumors and 40 healthy children as a control group). We investigated glutathione peroxidase, catalase and superoxide dismutase activities in erythrocytes. In these children we studied also catalase activity, ceruloplasmin concentration and antioxidant barrier level in plasma. We estimated antioxidant elements in patients with cancer before, during and after treatment and during remission and progression of the disease. The decrease of total antioxidant barrier was typical in introductory period of neoplastic disease. We observed the increase of superoxide dismutase and glutathione peroxidase in erythrocytes and catalase activity in plasma in children with clinical remission but we found the gradual decrease of ceruloplasmin level in plasma.
机体清除自由基能力的下降是促进肿瘤进程发展的因素之一。能够从机体清除自由基的酶和底物构成了抗氧化屏障。本研究的目的是评估肿瘤疾病患儿抗氧化机体屏障的某些元素。我们检查了100名年龄在6个月至16岁之间的儿童（60例恶性实体瘤患者和40名健康儿童作为对照组）。我们研究了红细胞中谷胱甘肽过氧化物酶、过氧化氢酶和超氧化物歧化酶的活性。在这些儿童中，我们还研究了血浆中的过氧化氢酶活性、铜蓝蛋白浓度和抗氧化屏障水平。我们评估了癌症患者在治疗前、治疗期间和治疗后以及疾病缓解和进展期间的抗氧化元素。肿瘤疾病初期总抗氧化屏障下降是典型现象。我们观察到临床缓解的儿童红细胞中超氧化物歧化酶和谷胱甘肽过氧化物酶增加，血浆中过氧化氢酶活性增加，但我们发现血浆中铜蓝蛋白水平逐渐下降。
