Biessels G J, Kappelle A C, Bravenboer B, Erkelens D W, Gispen W H
Department of Medical Pharmacology, Rudolf Magnus Institute, University of Utrecht, The Netherlands.
Diabetologia. 1994 Jul;37(7):643-50. doi: 10.1007/BF00417687.
Diabetes mellitus is a common metabolic disorder associated with chronic complications such as nephropathy, angiopathy, retinopathy and peripheral neuropathy. Diabetes is not often considered to have deleterious effects on the brain. However, long-term diabetes results in a variety of subtle cerebral disorders, which occur more frequently than is commonly believed. Diabetic cerebral disorders have been demonstrated at a neurochemical, electrophysiological, structural and cognitive level; however, the pathogenesis is still not clear. Probably alterations in cerebral blood supply and metabolic derangements play a role, as they do in the pathogenesis of diabetic neuropathy. Furthermore, the brain is also affected by recurrent episodes of hypoglycaemia and poor metabolic control. We describe herein the cerebral manifestations of diabetes and discuss the putative pathogenetic mechanisms.
糖尿病是一种常见的代谢紊乱疾病，与肾病、血管病、视网膜病变和周围神经病变等慢性并发症相关。糖尿病通常不被认为会对大脑产生有害影响。然而，长期糖尿病会导致多种细微的脑部疾病，其发生频率比通常认为的要高。糖尿病性脑部疾病已在神经化学、电生理、结构和认知水平上得到证实；然而，其发病机制仍不清楚。大脑血液供应的改变和代谢紊乱可能起了作用，就像它们在糖尿病性神经病变的发病机制中所起的作用一样。此外，大脑还会受到低血糖反复发作和代谢控制不佳的影响。我们在此描述糖尿病的脑部表现，并讨论可能的发病机制。
