Siraganian R P, Sandberg A L
J Allergy Clin Immunol. 1979 Jun;63(6):435-42. doi: 10.1016/0091-6749(79)90219-7.
The major allergens present in mouse skin, serum, and urine have been identified. Skin extracts, serum, and urine were chromatographed, and the activities of the fractions were monitored by histamine release from the leukocytes of individuals sensitive to mice. Fractionation of skin extracts revealed two major allergens. The large allergen has a molecular weight of approximately 67,000 daltons and by biochemical and immunochemical criteria appears to be identical to mouse albumin. The smaller molecular weight allergen is approximately 17,000 daltons. The same two allergens are also found in mouse serum and mouse urine. Histamine release by leukocytes of individuals allergic to mice demonstrated that some individuals react predominantly to the large allergen, some to the small allergen, and one group of patients reacts to both allergens.
已鉴定出存在于小鼠皮肤、血清和尿液中的主要过敏原。对皮肤提取物、血清和尿液进行了色谱分析，并通过对小鼠敏感个体白细胞组胺释放情况来监测各组分的活性。皮肤提取物的分级分离揭示了两种主要过敏原。较大的过敏原分子量约为67,000道尔顿，根据生化和免疫化学标准，它似乎与小鼠白蛋白相同。分子量较小的过敏原约为17,000道尔顿。在小鼠血清和小鼠尿液中也发现了同样的两种过敏原。对小鼠过敏个体的白细胞组胺释放情况表明，一些个体主要对大过敏原起反应，一些对小过敏原起反应，还有一组患者对两种过敏原都有反应。
