Phipatanakul Wanda
Children's Hospital, Harvard Medical School, Immunology, Fegan 6, 300 Longwood Avenue, Boston, MA 02115, USA.
Curr Allergy Asthma Rep. 2002 Sep;2(5):412-6. doi: 10.1007/s11882-002-0075-1.
Rodent allergens play a significant role in the pathogenesis of asthma and allergic rhinitis, and are potent causes of acute and chronic symptoms. This has long been apparent in occupational settings, particularly in the laboratory, but has been most recently studied and found to be important in home environments. These allergens have been suggested as uniquely important among inner-city children with asthma. Furthermore, rodents have become increasingly popular as pets. With recent awareness of significant exposure in a variety of settings, hypersensitivity to rodents has become increasingly important. This review focuses on the importance of rodent allergens, concentrating on mouse and rat, but including other potentially important rodents such as gerbil, hamster, and rabbit. It also discusses the pathogenesis, diagnosis, prevention, and management of rodent allergy.
啮齿动物过敏原在哮喘和过敏性鼻炎的发病机制中起重要作用,是急性和慢性症状的重要病因。长期以来,这在职业环境中,尤其是实验室环境中已很明显,但最近的研究发现其在家庭环境中也很重要。这些过敏原被认为在患有哮喘的城市儿童中具有独特的重要性。此外,啮齿动物作为宠物越来越受欢迎。随着最近人们意识到在各种环境中都存在大量接触,对啮齿动物的过敏反应变得越来越重要。本综述重点关注啮齿动物过敏原的重要性,主要集中在小鼠和大鼠,但也包括其他潜在重要的啮齿动物,如沙鼠、仓鼠和兔子。它还讨论了啮齿动物过敏的发病机制、诊断、预防和管理。