Blázquez M, Shennan K I
Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill.
Biochem Cell Biol. 2000;78(3):181-91.
Targeting proteins to their correct cellular location is crucial for their biological function. In neuroendocrine cells, proteins can be secreted by either the constitutive or the regulated secretory pathways but the mechanism(s) whereby proteins are sorted into either pathway is unclear. In this review we discuss the possibility that sorting is either an active process occurring at the level of the trans-Golgi network, or that sorting occurs passively in the immature granules, The possible involvement of protein-lipid interactions in the sorting process is also raised.
将蛋白质靶向至其正确的细胞位置对其生物学功能至关重要。在神经内分泌细胞中，蛋白质可通过组成型或调节型分泌途径分泌，但蛋白质被分选进入任一途径的机制尚不清楚。在本综述中，我们讨论了分选可能是发生在反式高尔基体网络水平的一个主动过程，或者分选在未成熟颗粒中被动发生的可能性，还提出了蛋白质-脂质相互作用在分选过程中可能的参与情况。
