四环素与强力霉素对粪便菌群中耐药性大肠杆菌出现的比较作用。
Comparative effect of tetracycline and doxycycline on the occurrence of resistant Escherichia coli in the fecal flora.
作者信息
Bartlett J G, Bustetter L A, Gorbach S L, Onderdonk A B
出版信息
Antimicrob Agents Chemother. 1975 Jan;7(1):55-7. doi: 10.1128/AAC.7.1.55.
Abstract
Antibiotic-induced changes in the fecal microflora after oral administration of tetracycline hydrochloride and doxycycline for 8 to 10 days were compared. A significant difference was noted in the concentrations of Escherichia coli resistant to tetracyclines. With tetracycline hydrochloride, there was a mean increase of approximately 10(4) resistant strains per g compared to only 10(1)/g for doxycycline. This difference is ascribed to reduced intestinal concentrations of bioactive drug with recommended oral dosage for doxycycline.
摘要
比较了口服盐酸四环素和强力霉素8至10天后抗生素诱导的粪便微生物群变化。观察到对四环素耐药的大肠杆菌浓度存在显著差异。使用盐酸四环素时，每克粪便中耐药菌株平均增加约10⁴个，而强力霉素仅为每克10¹个。这种差异归因于强力霉素推荐口服剂量下生物活性药物在肠道中的浓度降低。
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