Hirsh D C, Burton G C, Blenden D C
Antimicrob Agents Chemother. 1973 Jul;4(1):69-71. doi: 10.1128/AAC.4.1.69.
Serial samples of feces from normal human subjects were analyzed for tetracycline-resistant strains of Escherichia coli. Subjects were found to be excreting tetracycline-resistant strains in amounts fluctuating with time. Ingestion of tetracycline increased both the number of individuals excreting tetracycline-resistant strains of E. coli and the proportion of the total E. coli isolates resistant to the antibiotic.
对正常人类受试者的系列粪便样本进行了分析,以检测耐四环素的大肠杆菌菌株。发现受试者排出的耐四环素菌株数量随时间波动。摄入四环素会增加排出耐四环素大肠杆菌菌株的个体数量以及对该抗生素耐药的大肠杆菌分离株在总分离株中的比例。