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肌肽作为一种潜在的抗衰老药物。

Carnosine as a potential anti-senescence drug.

作者信息

Gallant S, Semyonova M, Yuneva M

机构信息

Zoetic Neurosciences Ltd., Leighton Buzzard, Beds, LU7 7NW, Great Britain.

出版信息

Biochemistry (Mosc). 2000 Jul;65(7):866-8.

PMID:10951107
Abstract

The naturally occurring dipeptide carnosine (beta-alanyl-L-histidine) has been found to exert an anti-senescence effect when used as a dietary supplement. Carnosine clearly improved the external appearance of experimental animals and provided beneficial physiological effects, thus maintaining the animals in better condition than control animals receiving no carnosine or a mixture of beta-alanine and L-histidine.

摘要

天然存在的二肽肌肽(β-丙氨酰-L-组氨酸)作为膳食补充剂使用时,已被发现具有抗衰老作用。肌肽显著改善了实验动物的外观,并产生了有益的生理效应,从而使这些动物比未接受肌肽或β-丙氨酸与L-组氨酸混合物的对照动物保持更好的状态。

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1
Carnosine as a potential anti-senescence drug.肌肽作为一种潜在的抗衰老药物。
Biochemistry (Mosc). 2000 Jul;65(7):866-8.
2
Retardation of the senescence of cultured human diploid fibroblasts by carnosine.肌肽延缓培养的人二倍体成纤维细胞衰老。
Exp Cell Res. 1994 Jun;212(2):167-75. doi: 10.1006/excr.1994.1132.
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Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress.肌肽在急性应激下对雏鸡产生的镇静和催眠作用的反向结构。
Life Sci. 2008 May 23;82(21-22):1065-9. doi: 10.1016/j.lfs.2008.03.015. Epub 2008 Apr 3.
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Glycation, ageing and carnosine: are carnivorous diets beneficial?糖基化、衰老与肌肽:肉食性饮食有益吗?
Mech Ageing Dev. 2005 Oct;126(10):1034-9. doi: 10.1016/j.mad.2005.05.002.
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Use of carnosine as a natural anti-senescence drug for human beings.肌肽作为一种用于人类的天然抗衰老药物的用途。
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Would carnosine or a carnivorous diet help suppress aging and associated pathologies?肌肽或肉食性饮食有助于抑制衰老及相关病变吗?
Ann N Y Acad Sci. 2006 May;1067:369-74. doi: 10.1196/annals.1354.052.
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[The pharmacological activity of carnosine].[肌肽的药理活性]
Eksp Klin Farmakol. 1995 Mar-Apr;58(2):66-74.
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On the enigma of carnosine's anti-ageing actions.肌肽抗衰之谜。
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Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation.组氨酸和肌肽可延缓小鼠糖尿病病情恶化,并保护人低密度脂蛋白免受氧化和糖化作用的影响。
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Carnosine: a versatile antioxidant and antiglycating agent.肌肽:一种多功能抗氧化剂和抗糖化剂。
Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12. doi: 10.1126/sageke.2005.18.pe12.

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