Brooks P M, Walker J J, Bell M A, Buchanan W W, Rhymer A R
Br Med J. 1975 Jul 12;3(5975):69-71. doi: 10.1136/bmj.3.5975.69.
Plasma profiles of indomethacin after a 50-mg oral dose were constructed in six healthy volunteers before and after a week of aspirin treatment. Aspirin did not interfere with indomethacin plasma levels. To examine the clinical effect of concurrent indomethacin and aspirin treatment 20 patients with seropositive rheumatoid arthritis were given indomethacin 100 mg/day, aspirin soluble 4 g/day, and the two drugs taken together in random order. Analysis of the clinical indices of inflammation--articular index and mean pain score--and of the efficacy of each treatment showed no significant differences between the three treatment groups. With the proliferation in the number of anti-rheumatic drugs available, the case for giving two or more nonsteroidal anti-inflammatory drugs concurrently remains unproved.
在六名健康志愿者中，于阿司匹林治疗一周前后测定了口服50毫克吲哚美辛后的血浆浓度曲线。阿司匹林不影响吲哚美辛的血浆水平。为了研究吲哚美辛与阿司匹林联合治疗的临床效果，20名血清阳性类风湿性关节炎患者被给予吲哚美辛100毫克/天、可溶性阿司匹林4克/天，且两种药物以随机顺序联合服用。对炎症的临床指标——关节指数和平均疼痛评分——以及每种治疗方法的疗效分析表明，三个治疗组之间没有显著差异。随着可用抗风湿药物数量的增加，同时给予两种或更多种非甾体抗炎药的情况仍未得到证实。
