临床琼氏不动杆菌和淋病奈瑟菌分离株中共轭mef基因的鉴定。
Identification of the conjugative mef gene in clinical Acinetobacter junii and Neisseria gonorrhoeae isolates.
作者信息
Luna V A, Cousin S, Whittington W L, Roberts M C
机构信息
Departments of Pathobiology, University of Washington, Seattle 98195, USA.
出版信息
Antimicrob Agents Chemother. 2000 Sep;44(9):2503-6. doi: 10.1128/AAC.44.9.2503-2506.2000.
Abstract
The mef gene, originally described for gram-positive organisms and coding for an efflux pump, has been identified in clinical isolates of Acinetobacter junii and Neisseria gonorrhoeae. These strains could transfer the mef gene at frequencies ranging from 10(-6) to 10(-9) into one or more of the following recipients: gram-negative Moraxella catarrhalis, Neisseria perflava/sicca and Neisseria mucosa and gram-positive Enterococcus faecalis. Three Streptococcus pneumoniae strains could transfer the mef gene into Eikenella corrodens, Haemophilus influenzae, Kingella denitrificans, M. catarrhalis, Neisseria meningitidis, N. perflava/sicca, and N. mucosa at similar frequencies. The mef gene can thus be transferred to and expressed in a variety of gram-negative recipients.
摘要
mef基因最初是在革兰氏阳性菌中发现的，编码一种外排泵，现已在琼氏不动杆菌和淋病奈瑟菌的临床分离株中鉴定出来。这些菌株能够以10^(-6)至10^(-9)的频率将mef基因转移至以下一种或多种受体菌中：革兰氏阴性的卡他莫拉菌、微黄奈瑟菌/干燥奈瑟菌和黏膜奈瑟菌，以及革兰氏阳性的粪肠球菌。三株肺炎链球菌菌株能够以相似频率将mef基因转移至腐蚀艾肯菌、流感嗜血杆菌、反硝化金氏菌、卡他莫拉菌、脑膜炎奈瑟菌、微黄奈瑟菌/干燥奈瑟菌和黏膜奈瑟菌中。因此，mef基因能够转移至多种革兰氏阴性受体菌中并在其中表达。
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