耐红霉素的淋病奈瑟菌和口腔共生奈瑟菌属携带已知的rRNA甲基化酶基因。
Erythromycin-resistant Neisseria gonorrhoeae and oral commensal Neisseria spp. carry known rRNA methylase genes.
作者信息
Roberts M C, Chung W O, Roe D, Xia M, Marquez C, Borthagaray G, Whittington W L, Holmes K K
机构信息
Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA.
出版信息
Antimicrob Agents Chemother. 1999 Jun;43(6):1367-72. doi: 10.1128/AAC.43.6.1367.
Abstract
Two Neisseria gonorrhoeae isolates from Seattle and two isolates from Uruguay were resistant to erythromycin (MIC, 4 to 16 microg/ml) and had reduced susceptibility to azithromycin (MIC, 1 to 4 microg/ml) due to the presence of the self-mobile rRNA methylase gene(s) ermF or ermB and ermF. The two Seattle isolates and one isolate from Uruguay were multiresistant, carrying either the 25.2-MDa tetM-containing plasmid (Seattle) or a beta-lactamase plasmid (Uruguay). Sixteen commensal Neisseria isolates (10 Neisseria perflava-N. sicca, 2 N. flava, and 4 N. mucosa) for which erythromycin MICs were 4 to 16 microg/ml were shown to carry one or more known rRNA methylase genes, including ermB, ermC, and/or ermF. Many of these isolates also were multiresistant and carried the tetM gene. This is the first time that a complete transposon or a complete conjugative transposon carrying an antibiotic resistance gene has been described for the genus Neisseria.
摘要
来自西雅图的两株淋病奈瑟菌分离株和来自乌拉圭的两株分离株对红霉素耐药（最低抑菌浓度[MIC]为4至16微克/毫升），并且由于存在可自我移动的rRNA甲基化酶基因ermF或ermB以及ermF，对阿奇霉素的敏感性降低（MIC为1至4微克/毫升）。来自西雅图的两株分离株和来自乌拉圭的一株分离株具有多重耐药性，携带25.2兆达尔含tetM质粒（西雅图）或β-内酰胺酶质粒（乌拉圭）。16株共生奈瑟菌分离株（10株微黄奈瑟菌-干燥奈瑟菌、2株黄奈瑟菌和4株黏膜奈瑟菌）的红霉素MIC为4至16微克/毫升，显示携带一个或多个已知的rRNA甲基化酶基因，包括ermB、ermC和/或ermF。这些分离株中的许多也具有多重耐药性并携带tetM基因。这是首次针对奈瑟菌属描述携带抗生素耐药基因的完整转座子或完整接合转座子。
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