早产儿碘摄入量与甲状腺状态的随机试验。
Randomised trial of iodine intake and thyroid status in preterm infants.
作者信息
Rogahn J, Ryan S, Wells J, Fraser B, Squire C, Wild N, Hughes A, Amegavie L
机构信息
Neonatal Unit, Liverpool Women's Hospital, Liverpool, UK.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2000 Sep;83(2):F86-90. doi: 10.1136/fn.83.2.f86.
BACKGROUND
Low levels of circulating thyroid hormones have been associated with poorer general and neurodevelopmental outcome in preterm babies and it has been speculated that the association is causal. Low levels of circulating thyroid hormone have been reported after inadequate intake of iodine in preterm infants being fed milk formula.
AIM
To investigate whether increased iodine intake from supplemented preterm formula would improve thyroid hormone levels in preterm babies (this study) and hence improve neurodevelopmental status (planned subsequent study).
METHOD
A total of 121 preterm infants were entered into a randomised controlled trial of standard (68 microg/l) versus increased (272 microg/l) iodine in preterm formula.
RESULTS
The two groups were comparable at recruitment. No evidence of an effect of the intervention on thyroid hormone levels was seen up to 41 weeks after conception.
CONCLUSION
Calls for increased iodine content of preterm infant formulas are not justified by this study.
背景
循环甲状腺激素水平低与早产儿较差的总体和神经发育结局相关，据推测这种关联具有因果关系。据报道，用配方奶喂养的早产儿碘摄入不足后，循环甲状腺激素水平会降低。
目的
研究补充碘的早产儿配方奶增加碘摄入量是否能改善早产儿的甲状腺激素水平（本研究），从而改善神经发育状况（计划中的后续研究）。
方法
121名早产儿参加了一项随机对照试验，比较标准碘含量（68微克/升）与增加碘含量（272微克/升）的早产儿配方奶。
结果
两组在招募时具有可比性。直到孕龄41周，未发现干预对甲状腺激素水平有影响的证据。
结论
本研究不支持增加早产儿配方奶碘含量的呼吁。
Zotero 插件