病毒免疫逃逸机制。
Viral mechanisms of immune evasion.
作者信息
Alcami A, Koszinowski U H
机构信息
Divn of Virology, Dept of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK CB2 1QP.
出版信息
Immunol Today. 2000 Sep;21(9):447-55. doi: 10.1016/s0167-5699(00)01699-6.
Abstract
During the millions of years they have coexisted with their hosts, viruses have learned how to manipulate host immune control mechanisms. Viral gene functions provide an overview of many relevant principles in cell biology and immunology. Our knowledge of viral gene functions must be integrated into virus-host interaction networks to understand viral pathogenesis, and could lead to new anti-viral strategies and the ability to exploit viral functions as tools in medicine.
摘要
在与宿主共存的数百万年里，病毒已经学会了如何操纵宿主的免疫控制机制。病毒基因功能概述了细胞生物学和免疫学中的许多相关原理。我们对病毒基因功能的了解必须融入病毒 - 宿主相互作用网络中，以理解病毒发病机制，这可能会带来新的抗病毒策略，并使我们有能力将病毒功能作为医学工具加以利用。
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