颠覆 stroke 康复领域：探索干细胞疗法的前景。
Revolutionizing Stroke Recovery: Unveiling the Promise of Stem Cell Therapy.
机构信息
Department of Neurology, Bern University Hospital Inselspital, Bern, Switzerland.
Department of Neurology, School of Medicine, University of Cyprus, Nicosia, Cyprus.
出版信息
Drug Des Devel Ther. 2024 Mar 29;18:991-1006. doi: 10.2147/DDDT.S460998. eCollection 2024.
Abstract
Stem cells, renowned for their unique regenerative capabilities, present significant hope in treating stroke, a major cause of disability globally. This review offers a detailed analysis of stem cell applications in stroke (ischemic and hemorrhagic) recovery. It examines therapies based on autologous (patient-derived), allogeneic (donor-derived), and Granulocyte-Colony Stimulating Factor (G-CSF) based stem cells, focusing on cell types such as Mesenchymal Stem/Stromal Cells (MSCs), Bone Marrow Mononuclear Stem Cells (BMMSCs), and Neural Stem/Progenitor Cells (NSCs). The paper compiles clinical trial data to evaluate their effectiveness and safety and addresses the ethical concerns of these innovative treatments. By explaining the mechanisms of stem cell-induced neurological repair, this review underscores stem cells' potential in revolutionizing stroke rehabilitation and suggests avenues for future research.
摘要
干细胞以其独特的再生能力而闻名，为治疗中风这一全球主要致残原因带来了重大希望。本综述详细分析了干细胞在中风（缺血性和出血性）康复中的应用。它考察了基于自体（患者来源）、同种异体（供体来源）和粒细胞集落刺激因子（G-CSF）的干细胞疗法，重点关注间充质干细胞/基质细胞（MSCs）、骨髓单个核干细胞（BMMSCs）和神经干细胞/祖细胞（NSCs）等细胞类型。本文汇集了临床试验数据，以评估它们的有效性和安全性，并探讨了这些创新疗法的伦理问题。通过解释干细胞诱导神经修复的机制，本综述强调了干细胞在中风康复领域的巨大潜力，并为未来的研究提供了思路。
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2
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