Ivanov I P, Gesteland R F, Atkins J F
Department of Human Genetics, University of Utah, 15N 2030E, Room 7410, Salt Lake City, UT 84112-5330, USA.
Nucleic Acids Res. 2000 Sep 1;28(17):3185-96. doi: 10.1093/nar/28.17.3185.
The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.
在解码抗酶mRNA过程中，程序性核糖体移码的效率是一种自动调节回路的传感器，该回路控制着从粟酒裂殖酵母到果蝇再到哺乳动物等多种生物体中的细胞多胺水平。现在，对许多生物体中移码位点和侧翼刺激信号的比较，使得参与移码的高度保守的mRNA序列可能的进化路径得以重建。
