Silverberg N B, Sidbury R, Mancini A J
Department of Pediatrics, Northwestern University Medical School, and the Division of Dermatology, Children's Memorial Hospital, Chicago, IL 60614, USA.
J Am Acad Dermatol. 2000 Sep;43(3):503-7. doi: 10.1067/mjd.2000.106370.
Molluscum contagiosum (MC) is a common cutaneous infection in children. Cantharidin, a chemovesicant that is highly effective in treating MC, has lost favor with some physicians because of concerns over its safety.
We attempted to determine the safety, efficacy, and parental satisfaction of cantharidin therapy for MC in children who were treated in a pediatric dermatology clinic at a large referral hospital.
A total of 537 charts of children who presented with MC were reviewed. We found 300 children who were treated with cantharidin and who had parents available for telephone interview, which was performed in addition to chart review.
With cantharidin therapy, 90% of patients experienced clearing and 8% improved. The average number of treatment visits was 2.1. Blisters occurred at sites of application in 92% of patients. Temporary burning, pain, erythema, or pruritus was reported in 6% to 37% of patients. No major side effects were reported, and no patients experienced secondary bacterial infection. A total of 95% of parents reported they would proceed with cantharidin therapy again.
To our knowledge ours is the largest retrospective series of childhood MC treated with cantharidin. In these patients the therapy was extremely effective and well tolerated, and parental satisfaction was high. Cantharidin is a safe and effective therapy for MC in children.
传染性软疣（MC）是儿童常见的皮肤感染。斑蝥素是一种对治疗MC非常有效的化学发泡剂，但由于对其安全性的担忧，一些医生已不再青睐它。
我们试图确定在一家大型转诊医院的儿科皮肤科诊所接受治疗的儿童中，斑蝥素治疗MC的安全性、有效性和家长满意度。
共查阅了537例患有MC的儿童病历。我们找到了300例接受斑蝥素治疗且其家长可接受电话访谈的儿童，除了查阅病历外还进行了电话访谈。
使用斑蝥素治疗后，90%的患者病情好转，8%的患者有所改善。平均治疗次数为2.1次。92%的患者在用药部位出现水疱。6%至37%的患者报告有短暂的烧灼感、疼痛、红斑或瘙痒。未报告有重大副作用，也没有患者发生继发性细菌感染。共有95%的家长表示他们会再次选择斑蝥素治疗。
据我们所知，我们的研究是使用斑蝥素治疗儿童MC的最大规模回顾性系列研究。在这些患者中，该治疗极其有效且耐受性良好，家长满意度较高。斑蝥素是治疗儿童MC的一种安全有效的疗法。
