Cathcart Shelley, Coloe Jacqueline, Morrell Dean S
Department of Dermatology, UNC Hospital, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Clin Pediatr (Phila). 2009 Mar;48(2):161-5. doi: 10.1177/0009922808326085. Epub 2008 Oct 20.
To study the efficacy, tolerability, and parental satisfaction of cantharidin in a patient population at a pediatric dermatology referral center.
Chart review was completed for 110 patients who presented with molluscum infection and were treated with cantharidin. A total of 54 were available for follow-up by telephone interview regarding adverse effects, parental satisfaction, and overall clearance of the infection.
Of those who were reachable, 96% improved after treatment with cantharidin. Parental satisfaction was 78%. Patients received an average of 2.2 treatments irrespective of outcome. Overall, 46% of patients experienced adverse events, including pain, pruritus, secondary infection, brisk immune response, and temporary hypopigmentation and 9% experienced an adverse event that they classified as severe.
The results contribute to the data supporting cantharidin as a safe and effective treatment of molluscum contagiosum. Compared with other treatments, it appears to be equally effective and well-tolerated and should be considered a potential front-line treatment.
在一家儿科皮肤科转诊中心的患者群体中研究斑蝥素的疗效、耐受性及家长满意度。
对110例患有传染性软疣并接受斑蝥素治疗的患者进行病历回顾。通过电话访谈，共有54例患者可供随访，内容涉及不良反应、家长满意度及感染的总体清除情况。
在可联系到的患者中，96%在接受斑蝥素治疗后病情改善。家长满意度为78%。无论治疗结果如何，患者平均接受2.2次治疗。总体而言，46%的患者经历了不良事件，包括疼痛、瘙痒、继发感染、强烈免疫反应、暂时性色素减退，9%的患者经历了他们认为严重的不良事件。
这些结果为支持斑蝥素作为传染性软疣的一种安全有效治疗方法的数据提供了补充。与其他治疗方法相比，它似乎同样有效且耐受性良好，应被视为一种潜在的一线治疗方法。
