Coloe Jacquelyn, Morrell Dean S
The Ohio State University College of Medicine, Columbus Ohio, Ohio, USA.
Pediatr Dermatol. 2009 Jul-Aug;26(4):405-8. doi: 10.1111/j.1525-1470.2008.00860.x.
Cantharidin is cited often in the dermatology and pediatric literature as a valuable treatment option for molluscum contagiosum (MC). However, there have been no prospective, randomized, vehicle-controlled trials that have been able to quantify cantharidin's efficacy in MC. The purpose of this study was to determine the breadth of usage of cantharidin, most frequently used protocols, and common side effects seen with use of cantharidin. An eighteen question survey was administered to the Society of Pediatric Dermatology. The survey sought to evaluate treatments used in MC and experiences with cantharidin including: protocol, side effects, specific products used, and satisfaction with cantharidin. A total of 300 surveys were distributed via email, 101 surveys were initiated, and 95 (94%) of these were completed. Cantharidin, imiquimod, benign neglect, curettage, cryotherapy, and retinoids were the most common approaches to pediatric MC reported by respondents. Ninety-two percent of respondents reported satisfaction with cantharidin's efficacy, but 79% reported side effects, with discomfort/pain and blistering being the most common. Cantharidin is a common modality in the treatment of MC among pediatric dermatologists. While efficacy data is still lacking, subjective satisfaction with cantharidin is reported. Cantharidin remains a viable treatment option for children with MC.
斑蝥素在皮肤科和儿科文献中经常被提及，是治疗传染性软疣（MC）的一种有价值的治疗选择。然而，尚无前瞻性、随机、赋形剂对照试验能够量化斑蝥素在MC治疗中的疗效。本研究的目的是确定斑蝥素的使用范围、最常用的方案以及使用斑蝥素时常见的副作用。对儿科皮肤病学会进行了一项包含18个问题的调查。该调查旨在评估MC的治疗方法以及使用斑蝥素的经验，包括：方案、副作用、使用的具体产品以及对斑蝥素的满意度。通过电子邮件共发放了300份调查问卷，启动了101份，其中95份（94%）完成。斑蝥素、咪喹莫特、观察等待、刮除术、冷冻疗法和维甲酸是受访者报告的治疗儿科MC最常见的方法。92%的受访者表示对斑蝥素的疗效满意，但79%的受访者报告有副作用，其中不适/疼痛和水疱形成最为常见。斑蝥素是儿科皮肤科医生治疗MC的常用方法。虽然仍然缺乏疗效数据，但有报告称对斑蝥素的主观满意度较高。斑蝥素仍然是患有MC儿童的一种可行治疗选择。
