通过鞘内注射减毒狂犬病疫苗延长狂犬病犬的发病期。
Prolonging morbidity in rabid dogs by intrathecal injection of attenuated rabies vaccine.
作者信息
Baer G M, Shaddock J H, Williams L W
出版信息
Infect Immun. 1975 Jul;12(1):98-103. doi: 10.1128/iai.12.1.98-103.1975.
Abstract
Dogs vaccinated intrathecally with attenuated rabies vaccine developed antibodies that were detected in the cerebrospinal fluid, blood, and brain; dogs similarly vaccinated but with an inactivated vaccine developed no antibodies in the brain. When the attenuated vaccine was administered to rabid dogs, a prolongation of the morbidity period was noted and, in some dogs, recovery from the disease. Rhesus monkeys died when administered any of the available attenuated vaccines intrathecally, and further studies with that species could not be undertaken.
摘要
经鞘内注射减毒狂犬病疫苗的犬只产生了可在脑脊液、血液和大脑中检测到的抗体；同样接受疫苗接种但使用的是灭活疫苗的犬只在大脑中未产生抗体。当给患狂犬病的犬只注射减毒疫苗时，观察到发病期延长，并且在一些犬只中出现了疾病康复的情况。恒河猴经鞘内注射任何一种可用的减毒疫苗后均死亡，因此无法对该物种进行进一步研究。
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