Clark R M, Capra N F, Halsey J H
J Neurosurg. 1975 Jul;43(1):1-8. doi: 10.3171/jns.1975.43.1.0001.
The authors report a method for measuring total local brain tissue pressure (BTP) using a miniature catheter transducer stereotaxically introduced into the white matter of the cat's cerebrum. Quantitative rapid phasic pressure changes were satisfactorily demonstrated. Due to some drift of baseline of the transducers and inability to perform in vivo calibration, reliable long-term quantitative pressure measurements sometimes could not be studied. The BTP from each cerebral hemisphere and the cisternal pressure (CP) were monitored during alterations of pCO-2 and systemic blood pressure, and distilled H20 injection prior to and after right middle cerebral artery (MCA) ligation. The catheter transducers functioned well on chronic implantation for up to 6 weeks. Compared to the chronically implanted catheters, acutely implanted catheters responded identically except for drift. The response of intracranial pressure and CP to MCA occlusion, alterations in pCO2, and systemic blood pressure were similar. No BTP gradients appeared in response to MCA ligation, hypercapnia, hypertension, or progressive swelling of the resulting infarction.
作者报告了一种使用微型导管换能器立体定向插入猫大脑白质来测量局部脑组织总压力（BTP）的方法。定量快速的相位压力变化得到了满意的证实。由于换能器基线存在一些漂移且无法进行体内校准，有时无法进行可靠的长期定量压力测量。在pCO₂和全身血压改变期间，以及在右侧大脑中动脉（MCA）结扎前后注射蒸馏水时，监测每个大脑半球的BTP和脑池压力（CP）。导管换能器在长期植入长达6周的情况下功能良好。与长期植入的导管相比，急性植入的导管除了漂移外反应相同。颅内压和CP对MCA闭塞、pCO₂改变和全身血压的反应相似。对MCA结扎、高碳酸血症、高血压或梗死灶逐渐肿胀，均未出现BTP梯度。
